The AXIN2 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to AXIN2, CEP112, and Conductin. This antibody recognizes Human, Mouse, and Rat antigen. The AXIN2 Polyclonal Antibody has been validated for the following applications: Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair